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Losartan should not be initiated during pregnancyUnless continued losartan therapy is considered essentialpatients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancyWhen pregnancy is diagnosedtreatment with losartan should be stopped immediatelyandif appropriatealternative therapy should be startedsee sections 4.3 and 4.6
The usual recommended starting dose is 0.7 mg per kg once dailyup to 50 mg totaladministered as a tablet or a suspensionsee DOSAGE AND ADMINISTRATIONDosage should be adjusted according to blood viagra samples free by mail, viagra samples free by mail, viagra samples free by mail, viagra samples free by mail, viagra samples free by mail, viagra samples free by mail. pressure responseDoses above 1.4 mg per kgor in excess of 100 mgdaily have not been studied in pediatric patientssee CLINICAL PHARMACOLOGYClinical Studiesand WARNINGS AND PRECAUTIONS
Losartan is a synthetic oral angiotensin-II receptortype AT 1antagonistAngiotensin IIa potent vasoconstrictoris the primary active hormone of the renin/angiotensin system and an important determinant of the pathophysiology of hypertensionAngiotensin II binds to the AT 1 receptor found in many tissuese.gvascular smooth muscleadrenal glandkidneys and the heartand elicits several important biological actionsincluding vasoconstriction and the release of aldosteroneAngiotensin II also stimulates smooth muscle cell proliferation.
There is no sufficient therapeutic experience with losartan in patients with heart failure and concomitant severe renal impairmentin patients with severe heart failureNYHA class IVas well as in patients with heart failure retin a canada pharmacy no prescription, cialis iskustva. and symptomatic life-threatening cardiac arrhythmiasThereforelosartan should be used with caution in these patient groupsThe combination of losartan with a beta-blocker should be used with cautionsee section 5.1
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